Article

Constitutive protein degradation induces acute cell death via proteolysis products

2023-02-06

Abstract excerpt

Modulation of proteolysis is an emerging therapeutic mainstay. The clinical success of thalidomide and analogs has inspired development of rationally-designed therapeutics that repurpose endogenous degradation machinery to target pathogenic proteins. However, it is unknown whether target removal is the critical effect that drives degrader-induced efficacy. Here we report that proteasome-generated peptides actively...

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Literature Corpus work: 08505adf-a9bd-5f23-badc-cb25e52a8b0a
DOI: 10.1101/2023.02.06.527237

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