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Article

Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924.

Molecular & cellular proteomics : MCP - 1 Nov 2011

Liao Hua, Liu Xiaozhen J, Blank Jonathan L, Bouck David C, Bernard Hugues, Garcia Khristofer, Lightcap Eric S

Abstract excerpt

Cullin-RING ubiquitin ligases (CRLs) are responsible for the ubiquitination of many cellular proteins, thereby targeting them for proteasomal degradation. In most cases the substrates of the CRLs have not been identified, although many of those that are known have cancer relevance. MLN4924, an investigational small molecule that is a potent and selective inhibitor of the Nedd8-activating enzyme (NAE), is...

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Identifiers

PMID: 21873567
DOI: 10.1074/mcp.M111.009183
PMCID: PMC3226404

Genes

NEDD8
EID1
KLF5
MAGEA6
MLX
MRFAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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