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Article

Manipulation of Epithelial Differentiation by HPV Oncoproteins

22 Apr 2019

Abstract excerpt

Papillomaviruses replicate and cause disease in stratified squamous epithelia. Epithelial differentiation is essential for the progression of papillomavirus replication, but differentiation is also impaired by papillomavirus-encoded proteins. The papillomavirus E6 and E7 oncoproteins partially inhibit and/or delay epithelial differentiation and some of the mechanisms by which they do so are beginning to be...

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PMID: 31013597
DOI: 10.3390/v11040369

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