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The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation

11 Jan 2021

Abstract excerpt

Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in over 99 % of cervical cancer cases, and a significant proportion of oropharyngeal and anogenital cancers. The key drivers of HPV-mediated transformation are the oncoproteins E5, E6 and E7. Together, they act to prolong cell-cycle progression, delay differentiation and inhibit apoptosis in the host keratinocyte cell in...

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PMID: 33427604
DOI: 10.1099/jgv.0.001540

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