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Article

GOOGA: A platform to synthesize mapping experiments and identify genomic structural diversity.

PLoS computational biology - 1 Apr 2019

Flagel Lex E, Blackman Benjamin K, Fishman Lila, Monnahan Patrick J, Sweigart Andrea, Kelly John K

Abstract excerpt

Understanding genomic structural variation such as inversions and translocations is a key challenge in evolutionary genetics. We develop a novel statistical approach to comparative genetic mapping to detect large-scale structural mutations from low-level sequencing data. The procedure, called Genome Order Optimization by Genetic Algorithm (GOOGA), couples a Hidden Markov Model with a Genetic Algorithm to analyze...

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Identifiers

PMID: 30986215
DOI: 10.1371/journal.pcbi.1006949
PMCID: PMC6483263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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