Article
Genomic Rearrangements in Arabidopsis Considered as Quantitative Traits.
Genetics - 1 Apr 2017
Imprialou Martha, Kahles André, Steffen Joshua G, Osborne Edward J, Gan Xiangchao, Lempe Janne, Bhomra Amarjit, Belfield Eric, Visscher Anne, Greenhalgh Robert, Harberd Nicholas P, Goram Richard, Hein Jotun, Robert-Seilaniantz Alexandre, Jones Jonathan, Stegle Oliver, Kover Paula, Tsiantis Miltos, Nordborg Magnus, Rätsch Gunnar, Clark Richard M, Mott Richard
Abstract excerpt
To understand the population genetics of structural variants and their effects on phenotypes, we developed an approach to mapping structural variants that segregate in a population sequenced at low coverage. We avoid calling structural variants directly. Instead, the evidence for a potential structural variant at a locus is indicated by variation in the counts of short-reads that map anomalously to that locus....
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