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Ultrasound microbubble-mediated CRISPR/Cas9 knockout of C-erbB-2 in HEC-1A cells

14 Apr 2019

Abstract excerpt

OBJECTIVE: Epidermal growth factor receptor 2 (C-erbB-2) is one of the most frequently mutated oncogenes in human tumors. We aimed to evaluate the knockout efficiency of clustered regularly interspaced short palindromic repeat (CRISPR) technology using ultrasound microbubble transfection to target C-erbB-2 in human endometrial cancer (HEC)-1A cells. METHODS: Three single guide RNAs (sgRNAs) targeting C-erbB-2...

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PMID: 30983484
DOI: 10.1177/0300060519840890

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