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Article

Changes in EGFR activity following CRISPR/Cas9-editing of the EGF binding domain.

Scientific reports - 31 Jan 2026

Popović Jelena, Hahut Anna, Torres Gabriel E, Vincent Andrew, Soto-Echevarria Nashaly, Wray Brian, Bartom Elizabeth T, Paunesku Tatjana, Goodman Chelain R, Woloschak Gayle E

Abstract excerpt

Elevated Epidermal Growth Factor Receptor (EGFR) expression is observed in most cervical cancers, and it is frequently associated with poor clinical outcomes. The limited efficacy of existing EGFR-targeted therapies in cervical cancer highlights the need for a deeper understanding of EGFR role in this cancer type. To investigate EGFR separately from its interaction with Epidermal Growth Factor (EGF), we removed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41620519
DOI: 10.1038/s41598-026-37579-8
PMCID: PMC12917122

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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