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Article

Drug-resistance reversal in colorectal cancer cells by destruction of flotillins, the key lipid rafts proteins

1 Jan 2019

Abstract excerpt

Multi-drug resistance (MDR) of tumor cells attenuates the efficacy of anticancer drugs and has become the main reason for chemotherapy failure. It is indispensable to establish an effective way to reverse multi-drug resistance. Our previous work has shown that down-regulation of the ERK/MAPK signaling pathway activity can reverse the drug-resistance of resistant cells. Further-more, the effect of signal...

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PMID: 30943747
DOI: 10.4149/neo_2018_180820n633

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