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Article

Establishment and Characterization of an Irinotecan-Resistant Human Colon Cancer Cell Line

22 Feb 2021

Abstract excerpt

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Irinotecan is widely used as a chemotherapeutic drug to treat CRC. However, the mechanisms of acquired resistance to irinotecan in CRC remain inconclusive. In the present study, we established a novel irinotecan-resistant human colon cell line to investigate the underlying mechanism(s) of irinotecan resistance, particularly the...

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PMID: 33692943
DOI: 10.3389/fonc.2020.624954

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