Article
Preferential β-arrestin signalling at low receptor density revealed by functional characterization of the human FSH receptor A189 V mutation.
Molecular and cellular endocrinology - 1 Jan 2011
Tranchant Thibaud, Durand Guillaume, Gauthier Christophe, Crépieux Pascale, Ulloa-Aguirre Alfredo, Royère Dominique, Reiter Eric
Abstract excerpt
The A189 V inactivating mutation of the human FSH receptor (FSHR) leads to subfertility in men and primary ovarian failure in women. This mutation has previously been associated with intracellular retention of the FSHR and impaired cAMP production. Here, we show that the A189 V FSHR stably expres...
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