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Article

Reactive oxygen species: a volatile driver of field cancerization and metastasis

30 Mar 2019

Abstract excerpt

Field cancerization and metastasis are the leading causes for cancer recurrence and mortality in cancer patients. The formation of primary, secondary tumors or metastasis is greatly influenced by multifaceted tumor-stroma interactions, in which stromal components of the tumor microenvironment (TME) can affect the behavior of the cancer cells. Many studies have identified cytokines and growth factors as cell...

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PMID: 30927919
DOI: 10.1186/s12943-019-0961-y

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