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Article

Metabolic phenotype of skeletal muscle in early critical illness.

Thorax - 1 Oct 2018

Puthucheary Zudin A, Astin Ronan, Mcphail Mark J W, Saeed Saima, Pasha Yasmin, Bear Danielle E, Constantin Despina, Velloso Cristiana, Manning Sean, Calvert Lori, Singer Mervyn, Batterham Rachel L, Gomez-Romero Maria, Holmes Elaine, Steiner Michael C, Atherton Philip J, Greenhaff Paul, Edwards Lindsay M, Smith Kenneth, Harridge Stephen D, Hart Nicholas, Montgomery Hugh E

Abstract excerpt

OBJECTIVES: To characterise the sketetal muscle metabolic phenotype during early critical illness. METHODS: Vastus lateralis muscle biopsies and serum samples (days 1 and 7) were obtained from 63 intensive care patients (59% male, 54.7±18.0 years, Acute Physiology and Chronic Health Evaluation II score 23.5±6.5). MEASUREMENTS AND MAIN RESULTS: From day 1 to 7, there was a reduction in mitochondrial beta-oxidation...

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PMID: 29980655
DOI: 10.1136/thoraxjnl-2017-211073

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