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Article

RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression

23 Mar 2019

Abstract excerpt

BACKGROUND: Prostate adenocarcinoma (AdPC) progression to treatment-induced neuroendocrine prostate cancer (t-NEPC) is associated with poor patient survival. While AdPC and t-NEPC share similar genomes, they possess distinct transcriptomes, suggesting that RNA splicing and epigenetic mechanisms may regulate t-NEPC development. OBJECTIVE: To characterize the role of alternative RNA splicing of the histone...

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PMID: 30910347
DOI: 10.1016/j.eururo.2019.03.011

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