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Article

Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer

20 Mar 2019

Abstract excerpt

loss, and aggressive clinical features. DLL3 in circulating tumor cells was concordant with matched metastatic biopsy (87%). Treatment of DLL3-expressing prostate cancer xenografts with a single dose of SC16LD6.5 resulted in complete and durable responses, whereas DLL3-negative models were insensitive. We highlight a patient with neuroendocrine prostate cancer with a meaningful clinical and radiologic response to...

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PMID: 30894499
DOI: 10.1126/scitranslmed.aav0891

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