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Delta-Like Protein 3 Expression and Targeting in Merkel Cell Carcinoma

5 May 2020

Abstract excerpt

PURPOSE: Delta-like protein 3 (DLL3) is being developed as a predictive biomarker for DLL3-targeting antibody-drug conjugate and other therapies. Given the neuroendocrine features of Merkel cell carcinoma (MCC), we sought to evaluate DLL3 expression and its role in MCC. EXPERIMENTAL DESIGN: Formalin-fixed and paraffin-embedded MCC cases were consecutively selected. Immunohistochemistry was performed for DLL3...

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PMID: 32372416
DOI: 10.1634/theoncologist.2019-0877

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