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Article

GSK-3β activation mediates apolipoprotein E4-associated cognitive impairment in type 2 diabetes mellitus: A multicenter, cross-sectional study.

Journal of diabetes - 1 Jan 2024

Gao Yang, Yu Haitao, Liu Yanchao, Xu Zhipeng, He Benrong, Liu Honghai, Wang Yuying, Zhang Yao, Liang Yi, Yang Ying, Zheng Jie, Wang Jian-Zhi

Abstract excerpt

AIM: Both the activation of glycogen synthase kinase-3β (GSK-3β) and the presence of ApoE ε4 genotype have been found to respectively correlate with cognitive decline in patients with type 2 diabetes mellitus (T2DM), who further show a high incidence of developing Alzheimer's disease. However, the relationship between ApoE ε4 and GSK-3β in the cognitive impairment of T2DM patients remains unclear. METHODS: ApoE...

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Identifiers

PMID: 37700547
DOI: 10.1111/1753-0407.13470
PMCID: PMC10809305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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