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Article

Type I interferon-mediated skewing of the serotonin synthesis is associated with severe disease in systemic lupus erythematosus.

PloS one - 1 Jan 2015

Lood Christian, Tydén Helena, Gullstrand Birgitta, Klint Cecilia, Wenglén Christina, Nielsen Christoffer T, Heegaard Niels H H, Jönsen Andreas, Kahn Robin, Bengtsson Anders A

Abstract excerpt

Serotonin, a highly pro-inflammatory molecule released by activated platelets, is formed by tryptophan. Tryptophan is also needed in the production of kynurenine, a process mediated by the type I interferon (IFN)-regulated rate-limiting enzyme indoleamine 2,3-dioxygenase (IDO). The aim of this study was to investigate levels of serotonin in patients with the autoimmune disease systemic lupus erythematosus (SLE),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25897671
DOI: 10.1371/journal.pone.0125109
PMCID: PMC4405357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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