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Mutant Lef1 controls Gata6 in sebaceous gland development and cancer

18 Mar 2019

Abstract excerpt

Abstract Mutations in Lef1 occur in human and mouse sebaceous gland (SG) tumors, but their contribution to carcinogenesis remains unclear. Since Gata6 controls lineage identity in SG, we investigated the link between these two transcription factors. Here, we show that Gata6 is a β‐catenin‐independent transcriptional target of mutant Lef1. During epidermal development, Gata6 is expressed in a subset of...

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Identifiers

PMID: 30886049
DOI: 10.15252/embj.2018100526

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