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Article

Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties.

Nature cell biology - 1 Jun 2017

Donati Giacomo, Rognoni Emanuel, Hiratsuka Toru, Liakath-Ali Kifayathullah, Hoste Esther, Kar Gozde, Kayikci Melis, Russell Roslin, Kretzschmar Kai, Mulder Klaas W, Teichmann Sarah A, Watt Fiona M

Abstract excerpt

The epidermis is maintained by multiple stem cell populations whose progeny differentiate along diverse, and spatially distinct, lineages. Here we show that the transcription factor Gata6 controls the identity of the previously uncharacterized sebaceous duct (SD) lineage and identify the Gata6 downstream transcription factor network that specifies a lineage switch between sebocytes and SD cells. During wound...

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Source

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Identifiers

PMID: 28504705
DOI: 10.1038/ncb3532
PMCID: PMC7610974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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