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Article

Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors

12 Mar 2019

Abstract excerpt

The molecular mechanisms leading to aryl hydrocarbon receptor interacting protein ( AIP ) mutation-induced aggressive, young-onset growth hormone-secreting pituitary tumors are not fully understood. In this study, we have identified that AIP -mutation-positive tumors are infiltrated by a large number of macrophages compared to sporadic tumors. Tissue from pituitary-specific Aip -knockout ( Aip Flox/Flox ;Hesx1...

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PMID: 30867568
DOI: 10.1038/s41388-019-0779-5

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