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DNA Methylation of Tumor Suppressor Genes in Pituitary Neuroendocrine Tumors

12 Nov 2018

Abstract excerpt

CONTEXT: Epigenetic alterations may play a role in the development and behavior of pituitary neuroendocrine tumors (PitNETs). OBJECTIVE: To evaluate the effect of methylation of tumor suppressor genes (TSGs) on their gene expression and on the behavior of PitNETs. MATERIAL AND METHODS: We used methylation-specific multiplex ligation-dependent probe amplification and quantitative real-time PCR techniques to...

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PMID: 30423170
DOI: 10.1210/jc.2018-01856

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