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Polymorphism Screening of Four Genes Encoding Advanced Glycation End-Product Putative Receptors

1 May 2001

Abstract excerpt

Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE receptors in 48 patients with type 1 diabetes and investigated the identified polymorphisms (n = 19) in...

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PMID: 11334430
DOI: 10.2337/diabetes.50.5.1214

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