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Article

Cluster-Transition Determining Sites Underlying the Antigenic Evolution of Seasonal Influenza Viruses

7 Mar 2019

Abstract excerpt

Seasonal influenza viruses undergo frequent mutations on their surface hemagglutinin (HA) proteins to escape the host immune response. In these mutations, a few key amino acid sites are associated with significant antigenic cluster transitions. To recognize the cluster-transition determining sites of seasonal influenza A/H3N2 and A/H1N1 viruses systematically and quickly, we developed a computational model named...

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PMID: 30851115
DOI: 10.1093/molbev/msz050

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