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Article

Biased N-Glycosylation Site Distribution and Acquisition across the Antibody V Region during B Cell Maturation

8 Mar 2019

Abstract excerpt

Abstract Abs can acquire N-linked glycans in their V regions during Ag-specific B cell responses. Among others, these N-linked glycans can affect Ag binding and Ab stability. Elevated N-linked glycosylation has furthermore been associated with several B cell–associated pathologies. Basic knowledge about patterns of V region glycosylation at different stages of B cell development is scarce. The aim of the current...

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PMID: 30850477
DOI: 10.4049/jimmunol.1801622

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