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Article

Variable domain N‐linked glycosylation and negative surface charge are key features of monoclonal ACPA: Implications for B‐cell selection

7 Mar 2018

Abstract excerpt

Abstract Autoreactive B cells have a central role in the pathogenesis of rheumatoid arthritis (RA), and recent findings have proposed that anti‐citrullinated protein autoantibodies (ACPA) may be directly pathogenic. Herein, we demonstrate the frequency of variable‐region glycosylation in single‐cell cloned mAbs. A total of 14 ACPA mAbs were evaluated for predicted N‐linked glycosylation motifs in silico, and...

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Identifiers

PMID: 29512823
DOI: 10.1002/eji.201747446

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Variable domain N‐linked glycosylation and negative surface charge are key features of monoclonal ACPA: Implications for B‐cell selectionPMID 29512823Read ↗

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