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Article

Elevated N-Linked Glycosylation of IgG V Regions in Myasthenia Gravis Disease Subtypes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2021

Mandel-Brehm Caleigh, Fichtner Miriam L, Jiang Ruoyi, Winton Valerie J, Vazquez Sara E, Pham Minh C, Hoehn Kenneth B, Kelleher Neil L, Nowak Richard J, Kleinstein Steven H, Wilson Michael R, DeRisi Joseph L, O'Connor Kevin C

Abstract excerpt

Elevated N-linked glycosylation of IgG V regions (IgG-VN-Glyc) is an emerging molecular phenotype associated with autoimmune disorders. To test the broader specificity of elevated IgG-VN-Glyc, we studied patients with distinct subtypes of myasthenia gravis (MG), a B cell-mediated autoimmune disease. Our experimental design focused on examining the B cell repertoire and total IgG. It specifically included adaptive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34544801
DOI: 10.4049/jimmunol.2100225
PMCID: PMC8492536

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