Article
Fusion partners of NTRK3 affect subcellular localization of the fusion kinase and cytomorphology of melanocytes.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2021
de la Fouchardière Arnaud, Tee Meng Kian, Peternel Sandra, Valdebran Manuel, Pissaloux Daniel, Tirode Franck, Busam Klaus J, LeBoit Philip E, McCalmont Timothy H, Bastian Boris C, Yeh Iwei
Abstract excerpt
A subset of Spitz tumors harbor fusions of NTRK3 with ETV6, MYO5A, and MYH9. We evaluated a series of 22 melanocytic tumors in which an NTRK3 fusion was identified as part of the diagnostic workup. Tumors in which NTRK3 was fused to ETV6 occurred in younger patients were predominantly composed of epithelioid melanocytes and were classified by their histopathologic features as Spitz tumors. In contrast, those in...
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