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Article

Potent Antineoplastic Effects of Combined PI3Kα–MNK Inhibition in Medulloblastoma

6 Mar 2019

Abstract excerpt

Abstract Medulloblastoma is a highly malignant pediatric brain tumor associated with poor outcome. Developing treatments that target the cancer stem cell (CSC) population in medulloblastoma are important to prevent tumor relapse and induce long-lasting clinical responses. We utilized medulloblastoma neurospheres that display CSC characteristics and found activation of the PI3K/AKT pathway in sphere-forming cells....

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PMID: 30842251
DOI: 10.1158/1541-7786.mcr-18-1193

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