Decoding human sperm signalling: Phosphoproteomic discovery of kinases governing fertilization competency

Abstract excerpt

<h4>ABSTRACT</h4> Capacitation, the process whereby sperm gain the functional competence to fertilize an egg in the absence of de novo transcription and translation, is orchestrated by a hierarchy of kinases driving the phosphorylation of sperm proteins. While increased phosphorylation, in particular tyrosine phosphorylation, is a revered hallmark of fertilization competency in our species, only a limited reposit...

Topics

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• 14-3-3 protein interactions
• Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Heat shock proteins research
• Neuropeptides and Animal Physiology
• Ovarian function and disorders
• Receptor Mechanisms and Signaling
• Reproductive Biology and Fertility
• Sperm and Testicular Function

Identifiers and source

Literature Corpus work

400c9750-ceae-517e-8658-0e089137d1bb

DOI

10.64898/2026.06.22.733301