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Article

Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains

27 Feb 2019

Abstract excerpt

The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and other neurological disorders. However, most transgenic TDP-43 rodent models show predominant nuclear distribution of TDP-43 in the brain. By expressing mutant TDP-43 (M337V) in the brains of rhesus monkeys and mice, we verified that...

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PMID: 30810811
DOI: 10.1007/s00401-019-01979-0

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