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Article

Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Jan 2010

Barmada Sami J, Skibinski Gaia, Korb Erica, Rao Elizabeth J, Wu Jane Y, Finkbeiner Steven

Abstract excerpt

Mutations in the gene encoding TDP-43-the major protein component of neuronal aggregates characteristic of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusion bodies-have been linked to familial forms of both disorders. Aggregates of...

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Identifiers

PMID: 20071528
DOI: 10.1523/JNEUROSCI.4988-09.2010
PMCID: PMC2821110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20071528-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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