Article

Aberrant Neural Activity in Prefrontal Pyramidal Neurons Lacking TDP-43 Precedes Neuron loss

2022-01-17

Abstract excerpt

<title>Abstract</title> <p>Background: Mislocalization of TAR DNA binding protein 43 kDa (TAPDBP, or TDP-43) is a principle pathological hallmark identified in cases of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). As an RNA binding protein, TDP-43 serves in the nuclear compartment to repress nonconserved cryptic exons to ensure the generation of a nor...

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Literature Corpus work: 68026069-0d97-54ea-95e2-66f91c1853b2
DOI: 10.21203/rs.3.rs-1215072/v1

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