Early experience with formalin-fixed paraffin-embedded (FFPE) based commercial clinical genomic profiling of gliomas-robust and informative with caveats.

doi:10.1016/j.yexmp.2017.06.006

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Early experience with formalin-fixed paraffin-embedded (FFPE) based commercial clinical genomic profiling of gliomas-robust and informative with caveats.

Experimental and molecular pathology - 1 Aug 2017

Movassaghi Masoud, Shabihkhani Maryam, Hojat Seyed A, Williams Ryan R, Chung Lawrance K, Im Kyuseok, Lucey Gregory M, Wei Bowen, Mareninov Sergey, Wang Michael W, Ng Denise W, Tashjian Randy S, Magaki Shino, Perez-Rosendahl Mari, Yang Isaac, Khanlou Negar, Vinters Harry V, Liau Linda M, Nghiemphu Phioanh L, Lai Albert, Cloughesy Timothy F, Yong William H

Abstract excerpt

BACKGROUND: Commercial targeted genomic profiling with next generation sequencing using formalin-fixed paraffin embedded (FFPE) tissue has recently entered into clinical use for diagnosis and for the guiding of therapy. However, there is limited independent data regarding the accuracy or robustness of commercial genomic profiling in gliomas. METHODS: As part of patient care, FFPE samples of gliomas from 71...

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PMID: 28663030
DOI: 10.1016/j.yexmp.2017.06.006

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IDH1
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