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Article

KCNMA1 Expression Is Downregulated in Colorectal Cancer via Epigenetic Mechanisms

19 Feb 2019

Abstract excerpt

KCNMA1 is a gene located at 10q22 that encodes the pore-forming α-subunit of the large-conductance Ca2+-activated K+ channel. KCNMA1 is down-regulated in gastric carcinoma tumors, through hypermethylation of its promoter. In the present study, we have evaluated the expression levels of KCNMA1 both in a mouse model of Colorectal Cancer (CRC) and in human CRC samples. Additionally, epigenetic mechanisms of KCNMA1...

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PMID: 30791468
DOI: 10.3390/cancers11020245

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