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Article

Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity

18 Feb 2019

Abstract excerpt

Cancer stem cells, also known as tumor-initiating cells (TICs), are a population of aggressive and self-renewing cells that are responsible for the initiation and progression of many cancers, including colorectal carcinoma. Intratumoral hypoxia, i.e. reduced oxygen supply following uncontrolled proliferation of cancer cells, is thought to support TIC activity by inducing specific hypoxia-responsive mechanisms...

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PMID: 30790680
DOI: 10.1016/j.canlet.2019.02.030

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