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Unveiling the role of microRNA‐7 in linking TGF‐β‐Smad‐mediated epithelial‐mesenchymal transition with negative regulation of trophoblast invasion

21 Feb 2019

Abstract excerpt

ABSTRACT Several pregnancy complications result from abnormal trophoblast invasion. The dichotomous effect of TGF‐β on epithelial‐mesenchymal transition (EMT) between trophoblast invasion and cancer progression remains unknown and a critical concern. We attenuated the expression of TGF‐β type 1 receptor (coding by TGFBR1 ) with RNA interference in trophoblastic cells and significantly enhanced the trophoblastic...

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PMID: 30789794
DOI: 10.1096/fj.201801898rr

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