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Article

MicroRNA-378a-5p promotes trophoblast cell survival, migration and invasion by targeting Nodal

1 Jan 2012

Abstract excerpt

Nodal is a member of the transforming growth factor-β superfamily that plays crucial roles during embryogenesis. Recently, we have reported that Nodal inhibits trophoblast cell proliferation, migration and invasion, but induces apoptosis in the human placenta. In this study, we examined the regulation of Nodal by microRNAs. In silico analysis of Nodal 3'UTR revealed a potential binding site for miR-378a-5p. In...

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PMID: 22454525
DOI: 10.1242/jcs.096412

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