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Article

Crystal Structure and Conformational Dynamics of Pyrococcus furiosus Prolyl Oligopeptidase.

Biochemistry - 26 Mar 2019

Ellis-Guardiola Ken, Rui Huan, Beckner Ryan L, Srivastava Poonam, Sukumar Narayanasami, Roux Benoît, Lewis Jared C

Abstract excerpt

Enzymes in the prolyl oligopeptidase family possess unique structures and substrate specificities that are important for their biological activity and for potential biocatalytic applications. The crystal structures of Pyrococcus furiosus ( Pfu) prolyl oligopeptidase (POP) and the corresponding S477C mutant were determined to 1.9 and 2.2 Å resolution, respectively. The wild type enzyme crystallized in an open...

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Identifiers

PMID: 30786206
DOI: 10.1021/acs.biochem.9b00031
PMCID: PMC6714975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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