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Article

Structural and mechanistic insights into lunatic fringe from a kinetic analysis of enzyme mutants.

The Journal of biological chemistry - 30 Jan 2009

Luther Kelvin B, Schindelin Hermann, Haltiwanger Robert S

Abstract excerpt

The Notch receptor is critical for proper development where it orchestrates numerous cell fate decisions. The Fringe family of beta1,3-N-acetylglucosaminyltransferases are regulators of this pathway. Fringe enzymes add N-acetylglucosamine to O-linked fucose on the epidermal growth factor repeats of Notch. Here we have analyzed the reaction catalyzed by Lunatic Fringe (Lfng) in detail. A mutagenesis strategy for...

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Identifiers

PMID: 19028689
DOI: 10.1074/jbc.M805502200
PMCID: PMC2631955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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