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Mdivi-1 and mitochondrial fission: recent insights from fungal pathogens

19 Feb 2019

Abstract excerpt

Mitochondrial fission shows potential as a therapeutic target in non-infectious human diseases. The compound mdivi-1 was identified as a mitochondrial fission inhibitor that acts against the evolutionarily conserved mitochondrial fission GTPase Dnm1/Drp1, and shows promising data in pre-clinical models of human pathologies. Two recent studies, however, found no evidence that mdivi-1 acts as a mitochondrial...

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Share to Antifungal resistance and susceptibility
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PMID: 30783741
DOI: 10.1007/s00294-019-00942-6

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