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Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition

19 Feb 2019

Abstract excerpt

Patients diagnosed with acute myeloid leukemia with complex karyotype (CK AML) have an adverse prognosis using current therapies, especially when accompanied by TP53 alterations. We hereby report the RNA-sequencing analysis of the 68 CK AML samples included in the Leucegene 415 patient cohort. We confirm the frequent occurrence of TP53 alterations in this subgroup and further characterize the allele expression...

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PMID: 30782614
DOI: 10.1182/bloodadvances.2018028480

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