Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway

15 Feb 2019

Abstract excerpt

Mitochondrial pyruvate carrier 1 (MPC1), a key factor that controls pyruvate transportation in the mitochondria, is known to be frequently dysregulated in tumor initiation and progression. However, the clinical relevance and potential molecular mechanisms of MPC1 in lung adenocarcinoma (LAC) progression remain to be illustrated. Herein, MPC1 was lowly expressed in LAC tissues and significantly associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Lung Cancer Treatments and Mutations
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30770798
DOI: 10.1038/s41419-019-1324-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathwayPMID 30770798Read ↗

CPS1 expression and its prognostic significance in lung adenocarcinomaSemantic proximity Read ↗

LncRNA TP73-AS1 promoted the progression of lung adenocarcinoma via PI3K/AKT pathwaySemantic proximity Read ↗

BCAT1 Promotes Lung Adenocarcinoma Progression Through Enhanced Mitochondrial Respiration and NF-κB Pathway ActivationSemantic proximity Read ↗

The Transcription Factor TEAD4 Enhances Lung Adenocarcinoma Malignancy through Enhancing PKM2 Mediated GlycolysisSemantic proximity Read ↗

Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells.Semantic proximity Read ↗

GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling.Semantic proximity Read ↗

PYCR1 knockdown inhibits the proliferation, migration, and invasion by affecting JAK/STAT signaling pathway in lung adenocarcinomaSemantic proximity Read ↗

HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway2Semantic proximity Read ↗

HIC1 attenuates invasion and metastasis by inhibiting the IL-6/STAT3 signalling pathway in human pancreatic cancerSemantic proximity Read ↗

LpCat1 Promotes Malignant Transformation of Hepatocellular Carcinoma Cells by Directly Suppressing STAT1Semantic proximity Read ↗

PCMT1 has Potential Prognostic Value and Promotes Cell Growth and Motility in Breast CancerSemantic proximity Read ↗

STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.