Article
The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Sept 2009
Mégarbané André, Ravel Aimé, Mircher Clotilde, Sturtz Franck, Grattau Yann, Rethoré Marie-Odile, Delabar Jean-Maurice, Mobley William C
Abstract excerpt
Trisomy 21 or Down syndrome is a chromosomal disorder resulting from the presence of all or part of an extra Chromosome 21. It is a common birth defect, the most frequent and most recognizable form of mental retardation, appearing in about 1 of every 700 newborns. Although the syndrome had been described thousands of years before, it was named after John Langdon Down who reported its clinical description in 1866....
Topics
- Animals
- Chromosomes, Human, Pair 21
- Clinical Trials as Topic
- Disease Models, Animal
- Down Syndrome
- Gene Dosage
- Genotype
- History, 20th Century
- History, 21st Century
- Humans