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Article

Dysregulation of autophagy in the central nervous system of sheep naturally infected with classical scrapie

13 Feb 2019

Abstract excerpt

Abstract Autophagy is a dynamic cellular mechanism involved in protein and organelle turnover through lysosomal degradation. Autophagy regulation modulates the pathologies associated with many neurodegenerative diseases. Using sheep naturally infected with scrapie as a natural animal model of prion diseases, we investigated the regulation of autophagy in the central nervous system (CNS) during the clinical phase...

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PMID: 30760781
DOI: 10.1038/s41598-019-38500-2

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