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An Update on Autophagy in Prion Diseases

27 Aug 2020

Abstract excerpt

Autophagy is a dynamic intracellular mechanism involved in protein and organelle turnover through lysosomal degradation. When properly regulated, autophagy supports normal cellular and developmental processes, whereas defects in autophagic degradation have been associated with several pathologies, including prion diseases. Prion diseases, or transmissible spongiform encephalopathies (TSE), are a group of fatal...

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PMID: 32984276
DOI: 10.3389/fbioe.2020.00975

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