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Article

Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging.

Neurobiology of aging - 1 Jan 2014

Sepe Sara, Nardacci Roberta, Fanelli Francesca, Rosso Pamela, Bernardi Cinzia, Cecconi Francesco, Mastroberardino Pier G, Piacentini Mauro, Moreno Sandra

Abstract excerpt

Autophagy is a major protein degradation pathway, essential for stress-induced and constitutive protein turnover. In nervous tissue, autophagy is constitutively active and crucial to neuronal survival. The efficiency of the autophagic pathway reportedly undergoes age-related decline, and autophagy defects are observed in neurodegenerative diseases. Since Ambra1 plays a fundamental role in regulating the...

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Identifiers

PMID: 23910655
DOI: 10.1016/j.neurobiolaging.2013.07.001

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