Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deregulation of autophagy in postmortem brains of Machado‐Joseph disease patients

8 Dec 2017

Abstract excerpt

Autophagy, the major pathway for protein turnover, is critical to maintain cellular homeostasis and has been implicated in neurodegenerative diseases. The aim of this research was to analyze the expression of autophagy markers in postmortem brains from Machado-Joseph disease (MJD) patients. The expression of autophagy markers in the cerebellum and the oculomotor nucleus from MJD patients and age-matched controls...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Lysosomal Storage Disorders Research
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29218765
DOI: 10.1111/neup.12433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deregulation of autophagy in postmortem brains of Machado‐Joseph disease patientsPMID 29218765Read ↗

Relevance of Autophagy and Mitophagy Dynamics and Markers in Neurodegenerative DiseasesSemantic proximity Read ↗

Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.Semantic proximity Read ↗

Emendation of autophagic dysfuction in neurological disorders: a potential therapeutic targetSemantic proximity Read ↗

Autophagy in motor neuron diseases.Semantic proximity Read ↗

Novel insights into the clinical and molecular spectrum of congenital disorders of autophagySemantic proximity Read ↗

Alteration of autophagosomal proteins in the brain of multiple system atrophySemantic proximity Read ↗

Autophagy in Spinocerebellar Ataxia Type 3: From Pathogenesis to TherapeuticsSemantic proximity Read ↗

Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration.Semantic proximity Read ↗

Brain Disorders Due to Lysosomal DysfunctionSemantic proximity Read ↗

Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neuronsSemantic proximity Read ↗

The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagySemantic proximity Read ↗

Influence of Normal Aging on Brain Autophagy: A Complex ScenarioSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.