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Article

Targeted therapy of acute myeloid leukemia.

Expert review of anticancer therapy - 1 Apr 2015

Carneiro Benedito A, Altman Jessica K, Kaplan Jason B, Ossenkoppele Gert, Swords Ronan, Platanias Leonidas C, Giles Francis J

Abstract excerpt

Advances in the understanding of the genetic underpinnings of acute myeloid leukemia are rapidly being translated into novel treatment strategies. Genomic profiling has highlighted the importance of the epigenetic machinery for leukemogenesis by identifying recurrent somatic mutations involving chromatin-modifier proteins. These genetic alterations function as dynamic regulators of gene expression and involve...

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Share to Antineoplastic Agents
Share to DNA Methyltransferase 3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 25623136
DOI: 10.1586/14737140.2015.1004316

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