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Article

Irregular telomeres impair meiotic synapsis and recombination in mice

14 Apr 2004

Abstract excerpt

Telomere shortening can lead to chromosome instability, replicative senescence, and apoptosis in both somatic and male germ cells. To study roles for mammalian telomeres in homologous pairing and recombination, we characterized effects of telomere shortening on spermatogenesis and oogenesis in late-generation telomerase-deficient mice. We show that shortened telomeres of late-generation telomerase-deficient mice...

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Share to DNA Repair Mechanisms
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PMID: 15084742
DOI: 10.1073/pnas.0400755101

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